Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake.

@article{MietlickiBaase2015CooperativeIB,
  title={Cooperative interaction between leptin and amylin signaling in the ventral tegmental area for the control of food intake.},
  author={Elizabeth G Mietlicki-Baase and Diana R Olivos and Brianne A Jeffrey and Matthew R Hayes},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2015},
  volume={308 12},
  pages={E1116-22}
}
Peripheral coadministration of amylin and leptin produces enhanced suppression of food intake and body weight, but the central nuclei mediating these effects remain unclear. Because each of these peptides controls feeding via actions at the ventral tegmental area (VTA), we tested the hypothesis that the VTA is a site of action for the cooperative effects of leptin and amylin on energy balance control. First, we show that intra-VTA injection of amylin and leptin at doses of each peptide that are… CONTINUE READING