Cooperative hydrogen bonding in amyloid formation.

  title={Cooperative hydrogen bonding in amyloid formation.},
  author={Kiril Tsemekhman and Lukasz Goldschmidt and David S Eisenberg and David Baker},
  journal={Protein science : a publication of the Protein Society},
  volume={16 4},
Amyloid diseases, including Alzheimer's and prion diseases, are each associated with unbranched protein fibrils. Each fibril is made of a particular protein, yet they share common properties. One such property is nucleation-dependent fibril growth. Monomers of amyloid-forming proteins can remain in dissolved form for long periods, before rapidly assembly into fibrils. The lag before growth has been attributed to slow kinetics of formation of a nucleus, on which other molecules can deposit to… CONTINUE READING

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