• Corpus ID: 53998249

Cooperative folding of muscle myosins: I. Mechanical model

  title={Cooperative folding of muscle myosins: I. Mechanical model},
  author={Matthieu Caruel and Jean-Marc Allain and Lev Truskinovsky},
  journal={arXiv: Biological Physics},
Mechanically induced folding of passive cross-linkers is a fundamental biological phenomenon. A typical example is a conformational change in myosin II responsible for the power-stroke in skeletal muscles. In this paper we present an athermal perspective on such folding by analyzing the simplest purely mechanical prototype: a parallel bundle of bi-stable units attached to a common backbone. We show that in this analytically transparent model, characterized by a rugged energy landscape, the… 
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