Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice.

@article{Wu2001CooperativeEO,
  title={Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice.},
  author={Jian Wu and Xin Xiang Wang and Misao Takasaki and Atsutane Ohta and Mitsuru Higuchi and Yoshiko Ishimi},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 10},
  pages={1829-36}
}
We reported that genistein, a soybean isoflavone, prevents bone loss caused by estrogen deficiency, without undesirable effects on the uterus. In this study, we examined cooperative effects of genistein administration and running exercise on bone mass in ovariectomized (OVX) mice. Female mice aged 7 weeks were either sham-operated or OVX and divided into six groups: (1) sham; (2) OVX; (3) OVX, treated with genistein at a submaximal dose (0.4 mg/day) subcutaneously (G); (4) OVX, exercised on a… CONTINUE READING
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