Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin function.

@article{Bobkov2006CooperativeEO,
  title={Cooperative effects of cofilin (ADF) on actin structure suggest allosteric mechanism of cofilin function.},
  author={Andrey A. Bobkov and Andras Muhlrad and Dmitry A Pavlov and Kaveh Kokabi and Atilgan Yilmaz and Emil Reisler},
  journal={Journal of molecular biology},
  year={2006},
  volume={356 2},
  pages={
          325-34
        }
}
Using site-specific fluorescence probes and cross-linking we demonstrated that cofilin (ADF), a key regulator of actin cellular dynamics, weakens longitudinal contacts in F-actin in a cooperative manner. Differential scanning calorimetry detected a dual nature of cofilin effects on F-actin conformation. At sub-stoichiometric cofilin to actin ratios, cofilin stabilized sterically and non-cooperatively protomers at the points of attachment, and destabilized allosterically and cooperatively… CONTINUE READING
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