Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat.

@article{Stenman2007CooperativeEO,
  title={Cooperative effect of angiotensin AT(1) and endothelin ET(A) receptor antagonism limits the brain damage after ischemic stroke in rat.},
  author={Emelie Stenman and Roya Jamali and Marie Henriksson and A. Maddahi and Lars Edvinsson},
  journal={European journal of pharmacology},
  year={2007},
  volume={570 1-3},
  pages={142-8}
}
Cerebral ischemia results in enhanced expression of smooth muscle cell endothelin and angiotensin receptors in cerebral arteries. We hypothesise that this phenomenon may be detrimental and that acute treatment with a combined non-hypotensive dose of the angiotensin AT(1) receptor inhibitor candesartan and the endothelin ET(A) receptor antagonist ZD1611 reduces the infarct in experimental ischemic stroke. Transient middle cerebral artery occlusion was induced in male Wistar rats by the… CONTINUE READING