Cooperative dynamics of a DNA polymerase replicating complex.

  title={Cooperative dynamics of a DNA polymerase replicating complex.},
  author={Samuel L. C. Moors and Piet Herdewijn and Johan Robben and Arnout Ceulemans},
  journal={Biochimica et biophysica acta},
  volume={1834 12},
Engineered DNA polymerases continue to be the workhorses of many applications in biotechnology, medicine and nanotechnology. However, the dynamic interplay between the enzyme and the DNA remains unclear. In this study, we performed an extensive replica exchange with flexible tempering (REFT) molecular dynamics simulation of the ternary replicating complex… CONTINUE READING