Cooperative dimerization of paired class homeo domains on DNA.

  title={Cooperative dimerization of paired class homeo domains on DNA.},
  author={David Sloan Wilson and Guojun Sheng and Thomas Lecuit and Nathalie Dostatni and Claude Desplan},
  journal={Genes & development},
  volume={7 11},
Homeo domain-containing proteins mediate many transcriptional processes in eukaryotes. Because nearly all animal homeo proteins are believed to bind to short, highly related DNA sequences, the basis for their high specificity of action is not understood. We show that cooperative dimerization on palindromic DNA sequences can provide increased specificity to one of the three major classes of homeo domains, the Paired/Pax class. The 60-amino-acid homeo domains from this class contain sufficient… CONTINUE READING
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