Cooperative damage recognition by UvrA and UvrB: identification of UvrA residues that mediate DNA binding.

Abstract

Nucleotide excision repair (NER) is responsible for the recognition and removal of numerous structurally unrelated DNA lesions. In prokaryotes, the proteins UvrA, UvrB and UvrC orchestrate the recognition and excision of aberrant lesions from DNA. Despite the progress we have made in understanding the NER pathway, it remains unclear how the UvrA dimer… (More)
DOI: 10.1016/j.dnarep.2007.11.013

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