Cooperative damage recognition by UvrA and UvrB: identification of UvrA residues that mediate DNA binding.

@article{Croteau2008CooperativeDR,
  title={Cooperative damage recognition by UvrA and UvrB: identification of UvrA residues that mediate DNA binding.},
  author={Deborah L. Croteau and Matthew J. DellaVecchia and Lalith Perera and Bennett van Houten},
  journal={DNA repair},
  year={2008},
  volume={7 3},
  pages={392-404}
}
Nucleotide excision repair (NER) is responsible for the recognition and removal of numerous structurally unrelated DNA lesions. In prokaryotes, the proteins UvrA, UvrB and UvrC orchestrate the recognition and excision of aberrant lesions from DNA. Despite the progress we have made in understanding the NER pathway, it remains unclear how the UvrA dimer interacts with DNA to facilitate DNA damage recognition. The purpose of this study was to define amino acid residues in UvrA that provide binding… CONTINUE READING

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