Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions.

Abstract

We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces exerted by the cell and these show that the cell-cell tugging stress is a constant and independent of the cell-cell junction area. In the current study, we demonstrate that a material model which includes the underlying cellular processes of stress fibre contractility and adhesion formation can capture these results. The simulations explain the experimentally observed phenomena whereby the cell-cell junction forces increase with junction size but the tractions exerted by the cell on the micro-post array are independent of the junction size. Further simulations on different types of micro-post arrays and cell phenotypes are presented as a guide to future experiments.

DOI: 10.1016/j.jbiomech.2014.11.025

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Cite this paper

@article{Ronan2015CooperativeCT, title={Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions.}, author={William J Ronan and Robert M. McMeeking and Christopher S. Chen and J. Patrick McGarry and Vikram Deshpande}, journal={Journal of biomechanics}, year={2015}, volume={48 3}, pages={520-8} }