Cooperative binding of transforming growth factor (TGF)-beta 2 to the types I and II TGF-beta receptors.

@article{Rodrguez1995CooperativeBO,
  title={Cooperative binding of transforming growth factor (TGF)-beta 2 to the types I and II TGF-beta receptors.},
  author={Cristina Rodr{\'i}guez and Feng Chen and Robin A. Weinberg and Harvey F. Lodish},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 27},
  pages={15919-22}
}
TGF-beta 1 binds with high affinity (KD = 25-50 pM) directly to the TGF-beta type II receptor serine-threonine kinase (T beta-RII) in the absence of expression of the TGF-beta type I or III receptors (T beta-RI and T beta-RIII). The serine-threonine kinase T beta-RI is essential for TGF-beta 1 signaling but not for binding to T beta-RII. TGF-beta 2, in… CONTINUE READING