Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements

@article{Tsai1989CooperativeBO,
  title={Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements},
  author={Sophia Y. Tsai and Bert W O'Malley},
  journal={Cell},
  year={1989},
  volume={57},
  pages={443-448}
}
We demonstrated previously that two molecules of steroid hormone receptor bound efficiently to a single hormone response element (GRE/PRE) of the tyrosine aminotransferase gene (Tsai et al., 1988). Here, we show that two tandemly linked GRE/PREs conferred progesterone inducibility synergistically to a heterologous TK-CAT fusion gene. Binding studies demonstrated that occupation of one GRE/PRE site by a progesterone receptor dimer increased the binding affinity of receptors for the second GRE… CONTINUE READING
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