Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase.

@article{Theissen2008CooperativeBO,
  title={Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase.},
  author={Bettina Theissen and Anne R. Karow and Juergen Koehler and Airat Gubaev and Dagmar Klostermeier},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 2},
  pages={548-53}
}
RNA helicases couple the energy from ATP hydrolysis with structural changes of their RNA substrates. DEAD box helicases form the largest class of RNA helicases and share a helicase core comprising two RecA-like domains. An opening and closing of the interdomain cleft during RNA unwinding has been postulated but not shown experimentally. Single-molecule FRET experiments with the Bacillus subtilis DEAD box helicase YxiN carrying donor and acceptor fluorophores on different sides of the… CONTINUE READING

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