Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

Abstract

The Ca2+/calmodulin-dependent protein phosphatase calcineurin (CN), a heterodimer composed of a catalytic subunit A and an essential regulatory subunit B, plays critical functions in various cellular processes such as cardiac hypertrophy and T cell activation. It is the target of the most widely used immunosuppressants for transplantation, tacrolimus (FK506… (More)
DOI: 10.1038/cr.2016.14

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