Cooperative assembly of signal recognition particle RNA with protein SRP19.

@article{Walker1995CooperativeAO,
  title={Cooperative assembly of signal recognition particle RNA with protein SRP19.},
  author={Kerfoot P Walker and Shaun D. Black and Christian Zwieb},
  journal={Biochemistry},
  year={1995},
  volume={34 37},
  pages={11989-97}
}
Signal recognition particle (SRP) is a ribonucleoprotein complex involved in the targeting of secretory proteins to the lipid bilayer of the endoplasmic reticulum. SRP contains the protein SRP19, which is an important structural and functional component, believed to promote the assembly of the particle. We have purified the human SRP19 protein to homogeneity from recombinant bacteria which overexpress the polypeptide, and have studied details of the binding to SRP RNA via gel mobility shift and… CONTINUE READING

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