Cooperative Recruitment of Dynamin and BIN/Amphiphysin/Rvs (BAR) Domain-containing Proteins Leads to GTP-dependent Membrane Scission*♦

@inproceedings{Meinecke2013CooperativeRO,
  title={Cooperative Recruitment of Dynamin and BIN/Amphiphysin/Rvs (BAR) Domain-containing Proteins Leads to GTP-dependent Membrane Scission*♦},
  author={Michael Meinecke and Emmanuel Boucrot and Gamze Çamdere and W. T. Hon and Rohit Mittal and Harvey T McMahon},
  booktitle={The Journal of biological chemistry},
  year={2013}
}
Dynamin mediates various membrane fission events, including the scission of clathrin-coated vesicles. Here, we provide direct evidence for cooperative membrane recruitment of dynamin with the BIN/amphiphysin/Rvs (BAR) proteins, endophilin and amphiphysin. Surprisingly, endophilin and amphiphysin recruitment to membranes was also dependent on binding to dynamin due to auto-inhibition of BAR-membrane interactions. Consistent with reciprocal recruitment in vitro, dynamin recruitment to the plasma… CONTINUE READING
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Membrane Recruitment of Dynamin and BAR Domain Proteins 6660 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • E J., O. Shupliakov
  • J. Cell Sci
  • 2013
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