Cooperative Gating between Single HCN Pacemaker Channels

@article{Dekker2006CooperativeGB,
  title={Cooperative Gating between Single HCN Pacemaker Channels},
  author={John P. Dekker and Gary Yellen},
  journal={The Journal of General Physiology},
  year={2006},
  volume={128},
  pages={561 - 567}
}
HCN pacemaker channels (I(f), I(q), or I(h)) play a fundamental role in the physiology of many excitable cell types, including cardiac myocytes and central neurons. While cloned HCN channels have been studied extensively in macroscopic patch clamp experiments, their extremely small conductance has precluded single channel analysis to date. Nevertheless, there remain fundamental questions about HCN gating that can be resolved only at the single channel level. Here we present the first detailed… CONTINUE READING
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