Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

@inproceedings{Fujita2018CooperativeDF,
  title={Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization},
  author={Hiroaki Fujita and Akira Tokunaga and Satoshi ImaiChihiro Shimizu and Amanda L. Whiting and Francisco Antonio Aguilar-Alonso and K. Takagi and Erik Walinda and Yoshiteru Sasaki and Taketo Shimokawa and Tsunehiro Mizushima and Izuru Ohki and Mariko Ariyoshi and Hidehito Tochio and F Sogan Dares Bernal and Masahiro Shirakawa and Kazuhiro Iwai},
  booktitle={Cell reports},
  year={2018}
}
The linear ubiquitin chain assembly complex (LUBAC) participates in inflammatory and oncogenic signaling by conjugating linear ubiquitin chains to target proteins. LUBAC consists of the catalytic HOIP subunit and two accessory subunits, HOIL-1L and SHARPIN. Interactions between the ubiquitin-associated (UBA) domains of HOIP and the ubiquitin-like (UBL) domains of two accessory subunits are involved in LUBAC stabilization, but the precise molecular mechanisms underlying the formation of stable… CONTINUE READING
BETA
3
Twitter Mentions

Figures and Topics from this paper.

Explore Further: Topics Discussed in This Paper

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Helix geometry in proteins.

  • Journal of molecular biology
  • 1988
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…