Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.

@article{Chen1993CooperativeDB,
  title={Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.},
  author={Xi Chen and George Farmer and Hongbo Zhu and Ron Prywes and Carol Prives},
  journal={Genes & development},
  year={1993},
  volume={7 10},
  pages={1837-49}
}
The p53 tumor-suppressor gene product, a sequence-specific DNA-binding protein, has been shown to act both as a transcriptional activator and repressor in vivo and in vitro. Consistent with its roles in regulating transcription are recent observations that p53 binds directly to the TATA box-binding protein (TBP) subunit of the basal transcription factor TFIID. Here, we show that p53 cooperates with either recombinant TBP or partially purified TFIID in binding to a DNA fragment containing both a… CONTINUE READING

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