Cooperation of the transcriptional coactivators CBP and p300 with Stat6.

  title={Cooperation of the transcriptional coactivators CBP and p300 with Stat6.},
  author={Christine McDonald and Nancy C. Reich},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={19 7},
Interleukin-4 (IL-4) functions as a critical regulatory cytokine of the immune response. A major effect of IL-4 is the induction of specific gene expression mediated by activation of a latent transcription factor, Stat6. To understand the mechanism by which Stat6 induces gene transcription, the effects of two histone acetylase coactivators, CREB binding protein (CBP) and p300, were evaluated. Both CBP and p300 were found to cooperate with Stat6 for induction of Stat6-dependent transcription… CONTINUE READING
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