Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium

@inproceedings{Yamasaki2013CooperationOT,
  title={Cooperation of the multidrug efflux pump and lipopolysaccharides in the intrinsic antibiotic resistance of Salmonella enterica serovar Typhimurium},
  author={Seiji Yamasaki and Saya Nagasawa and Aiko Fukushima and Mitsuko Hayashi-Nishino and Kunihiko Nishino},
  booktitle={The Journal of antimicrobial chemotherapy},
  year={2013}
}
OBJECTIVES In Gram-negative bacteria, drug susceptibility is associated with multidrug efflux systems and an outer membrane (OM) barrier. Previous studies revealed that Salmonella enterica serovar Typhimurium has 10 functional drug efflux pumps. Among them, AcrB is a major factor to maintain the intrinsic drug resistance in this organism. The lipopolysaccharide (LPS) content of OM is also important for resistance to lipophilic drugs; however, the interplay between the multidrug efflux pump and… CONTINUE READING
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