Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice

@article{Tsumura2006CooperationOO,
  title={Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice},
  author={Hiroshi Tsumura and Takafumi Yoshida and Hidehiko Saito and Kyoko Imanaka-Yoshida and Norio Suzuki},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={7673-7679}
}
Human rhabdomyosarcomas (RMSs) frequently demonstrate genetic alterations in ras and p53. To investigate their possible involvement in the tumorigenesis, we generated a knock-in mouse line with oncogenic K-ras, conditionally expressed by Cre/LoxP system on a background of p53 alteration. Electroporation of Cre expression vector in skeletal muscle tissues resulted in the generation of tumor in adults with tumor incidences of 100% at 10 weeks and 40% at 15 weeks, in p53−/− and p53−/+ backgrounds… CONTINUE READING

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