Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression

@article{Su2008CooperationOA,
  title={Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP–PKA signaling and immunosuppression},
  author={Yunyun Su and Xiaojun Huang and Tatiana Raskovalova and Lefteris Zacharia and Anna E. Lokshin and Edwin K Jackson and Elieser Gorelik},
  journal={Cancer Immunology, Immunotherapy},
  year={2008},
  volume={57},
  pages={1611-1623}
}
We hypothesize that adenosine and PGE2 could have a complementary immunosuppressive effect that is mediated via common cAMP-PKA signaling. To test this hypothesis, the effect of adenosine and PGE2 on the cytotoxic activity and cytokine production of lymphokine activated killer (LAK) cells was investigated. PGE2 and adenosine inhibited LAK cells cytotoxic activity and production of INF-γ, GM-CSF and TNF-α. In combination they showed substantially higher inhibition than each modality used alone… CONTINUE READING