Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models

@inproceedings{Chen2017CooperationOO,
  title={Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models},
  author={Chun-Yu Chen and Pin-Yi Wang and Brian J. Hutzen and Les Sprague and Hayley M. Swain and J. Kejrr Love and Joseph R Stanek and Louis Boon and J. Conner and Timothy P Cripe},
  booktitle={Scientific Reports},
  year={2017}
}
Oncolytic virotherapy is an effective immunotherapeutic approach for cancer treatment via a multistep process including direct tumor cell lysis, induction of cytotoxic or apoptosis-sensitizing cytokines and promotion of antitumor T cell responses. Solid tumors limit the effectiveness of immunotherapeutics in diverse ways such as secretion of immunosuppressive cytokines and expression of immune inhibitory ligands to inhibit antitumor T cell function. Blocking programmed cell death protein (PD)-1… CONTINUE READING
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