Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity.

@article{Aligeti2015CooperationBT,
  title={Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity.},
  author={Mounavya Aligeti and Allison E Roder and Stacy M Horner},
  journal={Journal of virology},
  year={2015},
  volume={89 22},
  pages={
          11523-33
        }
}
UNLABELLED The molecular mechanisms that govern hepatitis C virus (HCV) assembly, release, and infectivity are still not yet fully understood. In the present study, we sequenced a genotype 2A strain of HCV (JFH-1) that had been cell culture adapted in Huh-7.5 cells to produce nearly 100-fold-higher viral titers than the parental strain. Sequence analysis identified nine mutations in the genome, present within both the structural and nonstructural genes. The infectious clone of this virus… CONTINUE READING
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