Cooperation between pathologists and clinicians allows a better diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms.

@article{Gianelli2014CooperationBP,
  title={Cooperation between pathologists and clinicians allows a better diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms.},
  author={Umberto Gianelli and Alessandra Iurlo and Daniele Cattaneo and Giorgio Lambertenghi-Deliliers},
  journal={Expert review of hematology},
  year={2014},
  volume={7 2},
  pages={255-64}
}
As no specific genetic lesions have yet been identified, the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms is based on a simultaneous evaluation of the clinical, morphological and molecular features defined by the updated WHO classification, which allow most cases of full-blown disease to be classified. Nevertheless, about 10-15% of the patients have unclassifiable myeloproliferative neoplasms, most of whom are in the prodromal (early) phase of disease and… CONTINUE READING