Cooperation between p53 and hMLH1 in a human colocarcinoma cell line in response to DNA damage.

Abstract

We have studied the possible interactions between the mismatch repair system and p53 in a human colon cancer cell line, HCT-116 (known to have a homozygous mutation in mismatch repair gene hMLH1 on chromosome 3) and in a clone obtained after insertion of a single copy of chromosome 3 (HCT-116+ ch3). Loss of DNA mismatch repair activity resulted in… (More)

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@article{Vikhanskaya1999CooperationBP, title={Cooperation between p53 and hMLH1 in a human colocarcinoma cell line in response to DNA damage.}, author={Faina Vikhanskaya and Giuseppe Colella and Melanie Valenti and S. Parodi and Maurizio D'Incalci and Massimo Broggini}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={1999}, volume={5 4}, pages={937-41} }