Cooperation between Rb and Arf in suppressing mouse retinoblastoma.

Abstract

Retinoblastoma is a pediatric cancer that has served as a paradigm for tumor suppressor gene function. Retinoblastoma is initiated by RB gene mutations, but the subsequent cooperating mutational events leading to tumorigenesis are poorly characterized. We investigated what these additional genomic alterations might be using human retinoblastoma samples and… (More)
DOI: 10.1172/JCI61403

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