Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation.

@article{Ouyang2007CooperationBM,
  title={Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation.},
  author={Xinshou Ouyang and Hideo Negishi and Rie Takeda and Yasuyuki Fujita and T. Taniguchi and Kenya Honda},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 4},
  pages={1045-51}
}
Signaling by Toll-like receptors (TLRs) is central to evoking innate immunity, wherein each TLR is activated by distinct pathogen-derived agonists. It has been shown previously that TLR signaling occurs in synergy when certain TLR agonist combinations simultaneously activate immune cells. This synergism may constitute a mechanism critical to ensuring the effective activation of the immune system by multiple TLR activating molecules associated with a given pathogen; however, its underlying… CONTINUE READING
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