Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples

@article{Shih2008CooperatingMO,
  title={Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples},
  author={L -Y Shih and D-c Liang and C -F Huang and Yongfeng Chang and C-l Lai and T-h Lin and Changqing Yang and I Hung and Huizhong Liu and T L Jaing and L Wang and T-C Yeh},
  journal={Leukemia},
  year={2008},
  volume={22},
  pages={303-307}
}
c-KIT mutations have been described in core-binding factor (CBF) acute myeloid leukemia (AML) at diagnosis. The role of c-KIT mutations in the relapse of CBF–AML is not clear. The role of CSF1R mutation in the pathogenesis of AML remains to be determined. We analyzed receptor tyrosine kinases (RTKs) and Ras mutations on 154 children with AML. Also, we examined the paired diagnosis and relapse samples in CBF–AML. CBF–AML accounted for 27% (41/154). c-KIT mutations were detected in 41.5% of CBF… CONTINUE READING
Highly Cited
This paper has 62 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

63 Citations

051015'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 63 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 42 references

( CBF - AML )

A Shimada, T Taki, +3 authors M Tsuchida
2006

and MLL rearrangement

DC Liang, TT Chan, +3 authors SH Chen
Leukemia • 2006

myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group

RS Care, PJ Valk, +3 authors GA Wilson
Blood • 2006