Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury.

@article{Sahuquillo2007CoolingTI,
  title={Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury.},
  author={Juan Sahuquillo and Anna Vilalta},
  journal={Current pharmaceutical design},
  year={2007},
  volume={13 22},
  pages={
          2310-22
        }
}
Neither any neuroprotective drug has been shown to be beneficial in improving the outcome of severe traumatic brain injury (TBI) nor has any prophylactically-induced moderate hypothermia shown any beneficial effect on outcome in severe TBI, despite the optimism generated by preclinical studies. This contrasts with the paradox that hypothermia still is the most powerful neuroprotective method in experimental models because of its ability to influence the multiple biochemical cascades that are… CONTINUE READING

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