Cooling strategies and transport theories for brain hypothermia resuscitation

  title={Cooling strategies and transport theories for brain hypothermia resuscitation},
  author={Liu Jing},
  journal={Frontiers in energy},
  • Liu Jing
  • Published 5 March 2007
  • Medicine
  • Frontiers in energy
The brain is one of the most important organs in a biological body whose normal function depends heavily on an uninterrupted delivery of oxygen. Unlike skeletal muscles that can survive for hours without oxygen, neuron cells in the brain are easily subjected to an irreversible damage within minutes from the onset of oxygen deficiency. With the interruption of cardiopulmonary circulation in many cardiac surgical procedures or accidental events leading to cerebral circulation arrest, an imbalance… Expand
3 Citations
Multi-scale modeling on human intravascular cooling to induce brain hypothermia via circle of Willis
Results show that carotid artery intervention is a more suitable therapeutic hypothermia method in comparison with femoral artery or femoral vein intervention, which could help design controlling software for intravascular therapeutic Hypothermia device in the near future. Expand
Mechanism interpretation of the biological brain cooling and its inspiration on bionic engineering
The brain is one of the most important organs in a biological body which can only work in a relatively stable temperature range. However, many environmental factors in biosphere would cause cerebralExpand
Evaluation of human brain hyperthermia using exergy balance equation.
The results indicate that the exergy-based approach is well suited to model hyperthermia at pathophysiological boundaries, contrary to existing approaches which predominantly are limited to the physiological domain. Expand


Numerical studies on the effect of lowering temperature on the oxygen transport during brain hypothermia resuscitation
  • Yan Ji, Jing Liu
  • Chemistry, Computer Science
  • Comput. Biol. Medicine
  • 2002
A heat transfer model was established to characterize the thermal response of brain tissue during hypothermia resuscitation and a compartmental model taking account of the temperature effect was further developed to analyze the transient oxygen partial pressure distribution over the successive branches of the vascular network during circulation arrest. Expand
Effect of deep hypothermia and circulatory arrest on cerebral blood flow and metabolism.
Examining flow and metabolism serially in the postoperative period shows that in the majority of patients, flow, metabolism and autoregulation return to normal within 24 hours after operation, and it is likely that low cardiac output and pressure-passive cerebral blood flow potentiate brain ischemia after cardiopulmonary bypass and operation in some patients. Expand
New conceptual method for directly cooling the target biological tissues
Hypothermia is a commonly adopted strategy to decrease the cerebral oxygen demands, which is critical for the patient to sustain longer time when subjected to a hypoxia. However, when circulatoryExpand
Capacity of Brain Cooling Via Ventilating Oxygen at Low Temperature Over Respiratory Tract
  • Yong-gang Lv, J. Liu
  • Medicine
  • 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
  • 2005
Calculation results indicate that COV will help in some extent to reduce the inner temperature of patient brain subject to cerebral circulation arrest, but its capacity on lowering the deep brain temperature is very limited. Expand
Preliminary study on the oxygen consumption dynamics during brain hypothermia resuscitation
  • Yan Ji, J. Liu
  • Medicine
  • 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2001
Based on the classical Pennes bioheat equation and oxygen diffusion equation, a new coupled heat-mass transfer model for characterizing the cerebral circulatory arrest is proposed and it is shown that the surface cooling contributes little to depress the oxygen consumption, which received few attentions before. Expand
Rapid and selective cerebral hypothermia achieved using a cooling helmet.
This cooling helmet delivers initial rapid and selective brain cooling and maintains a significant temperature gradient between the core and brain temperatures throughout the hypothermic period to provide sufficient regional hypothermia yet minimize systemic complications. Expand
Theoretical simulation of temperature distribution in the brain during mild hypothermia treatment for brain injury
  • L. Zhu, C. Diao
  • Chemistry, Medicine
  • Medical and Biological Engineering and Computing
  • 2006
A theoretical model was developed to examine the brain temperature gradients during selective cooling of the brain surface after head injury, showing that the volumetric-averaged brain tissue temperature Tbt, avg for adults and infants can be 1.7 and 4.3°C lower than the temperature of the arterial blood supplied to the brain tissue. Expand
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  • Chemistry, Medicine
  • Annual review of physiology
  • 1982
The process has been studied most intensively in panting carnivores and artiodactyls in which the structure of the nasal cavity and the arrangement of the blood vessels of the nose and the brain are well-suited for brain cooling. Expand
Mathematical analysis of haemodilution's direct effect on rate of brain cooling during cardiopulmonary bypass
  • F. Dexter
  • Medicine
  • Medical and Biological Engineering and Computing
  • 2006
It is concluded that, within the haemotocrit range used clinically during bypass, haemodilution with these substances has only a small direct effect on the rate of brain cooling. Expand
Rapid development of brain hypothermia using femoral-carotid bypass.
  • K. Mori, J. Saito, +6 authors E. Dickson
  • Medicine
  • Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
  • 2001
Femoral-carotid hypothermic bypass rapidly induced a state of selective brain hypothermia without causing systemic hypthermia or hemodynamic instability in patients initially surviving sudden cardiac arrest. Expand