Convulxin forms a dimer in solution and can bind eight copies of glycoprotein VI: implications for platelet activation.

Abstract

Convulxin (CVX) is a C-type lectin-like protein from the venom of the South American rattlesnake that functions as a potent agonist of the platelet collagen receptor glycoprotein VI (GPVI). Although CVX is widely used as a platelet agonist, the molecular basis for its extremely high potency is not clear. In order to delineate possible mechanisms for CVX… (More)
DOI: 10.1021/bi801820q

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