Converting enzyme activity and angiotensin metabolism in the dog brainstem.

@article{Santos1988ConvertingEA,
  title={Converting enzyme activity and angiotensin metabolism in the dog brainstem.},
  author={Robson Santos and K. Bridget Brosnihan and Mark C. Chappell and Jes{\'u}s Pesquero and Cheryl L Chernicky and Lewis Joel Greene and Carlos Maria Ferrario},
  journal={Hypertension},
  year={1988},
  volume={11 2 Pt 2},
  pages={I153-7}
}
The concentrations of angiotensin converting enzyme (ACE) activity, norepinephrine, and serotonin were measured in microdissected regions of the dog's brainstem and spinal cord. In addition, we determined the in vitro metabolism of 125I-angiotensin I (Ang I) in homogenates of the same brain punch regions. High ACE-specific activity was found in the monoamine-containing regions of the brainstem and in the intermediolateral column of the spinal cord. In brainstem homogenates 125I-Ang I was… CONTINUE READING

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