Converting a eukaryotic transcriptional inhibitor into an activator.

@article{Ma1988ConvertingAE,
  title={Converting a eukaryotic transcriptional inhibitor into an activator.},
  author={Jianguo Ma and Mark Ptashne},
  journal={Cell},
  year={1988},
  volume={55 3},
  pages={443-6}
}
GAL80, an inhibitor of the yeast transcriptional activator GAL4, is converted into an activator by inserting an acidic activating sequence into it. This hybrid activator does not bind to DNA directly, but is brought to DNA by interacting with a derivative of GAL4 that interacts with both DNA and GAL80. 

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