Convertible visceral fat as a therapeutic target to curb obesity

@article{Giordano2016ConvertibleVF,
  title={Convertible visceral fat as a therapeutic target to curb obesity},
  author={A. Giordano and A. Frontini and S. Cinti},
  journal={Nature Reviews Drug Discovery},
  year={2016},
  volume={15},
  pages={405-424}
}
New therapeutic and preventative strategies are needed to address the growing obesity epidemic. In animal models, brown adipose tissue activation and the associated heat produced contribute to countering obesity and the accompanying metabolic abnormalities. Adult humans also have functional brown fat. Here, we present and discuss the concepts of murine and human white adipose tissue plasticity and the transdifferentiation of white adipocytes into brown adipocytes. Human visceral adipocytes… Expand
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