Convertible visceral fat as a therapeutic target to curb obesity

  title={Convertible visceral fat as a therapeutic target to curb obesity},
  author={Antonio Giordano and Andrea Frontini and Saverio Cinti},
  journal={Nature Reviews Drug Discovery},
New therapeutic and preventative strategies are needed to address the growing obesity epidemic. In animal models, brown adipose tissue activation and the associated heat produced contribute to countering obesity and the accompanying metabolic abnormalities. Adult humans also have functional brown fat. Here, we present and discuss the concepts of murine and human white adipose tissue plasticity and the transdifferentiation of white adipocytes into brown adipocytes. Human visceral adipocytes… 

MicroRNAs in adipocyte formation and obesity.

  • M. Scheideler
  • Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2016

Recent developments in natural products for white adipose tissue browning.

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A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

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MicroRNA networks regulate development of brown adipocytes

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.

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