Convertible manganese contrast for molecular and cellular MRI.

  title={Convertible manganese contrast for molecular and cellular MRI.},
  author={Erik M. Shapiro and Alan P. Koretsky},
  journal={Magnetic resonance in medicine},
  volume={60 2},
We describe here the use of inorganic manganese based particles as convertible MRI agents. As has been demonstrated with iron oxide particles, manganese oxide and manganese carbonate particles can be internalized within phagocytotic cells, being subsequently shuttled to endosomes and/or lysosomes. As intact particles, only susceptibility-induced MRI contrast is exhibited, most often seen as dark contrast in susceptibility-weighted images. Modulation of MRI contrast is accomplished by the… CONTINUE READING
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