Corpus ID: 15361061

Conversion to Armour Thyroid from Levothyroxine Improved Patient Satisfaction in the Treatment of Hypothyroidism

@inproceedings{Pepper2014ConversionTA,
  title={Conversion to Armour Thyroid from Levothyroxine Improved Patient Satisfaction in the Treatment of Hypothyroidism},
  author={Gary M. Pepper and Paul Casanova-Romero},
  year={2014}
}
The use of Armour Thyroid (desiccated thyroid) in the treatment of hypothyroidism has generated debate among endocrinologists although there is evidence that a significant percentage of patients prefer this medication to T4-only replacement strategies. [...] Key Method Results: On a 5 point Satisfaction Rating Scale with “5” indicative of the highest level of satisfaction, 117 (78.0%) patients gave a score of greater than “3” in preference for AT.Expand
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References

SHOWING 1-10 OF 22 REFERENCES
Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study.
TLDR
DTE therapy did not result in a significant improvement in quality of life; however, DTE caused modest weight loss and nearly half (48.6%) of the study patients expressed preference for DTE over L-T₄, which may be relevant for some hypothyroid patients. Expand
Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for graves’ disease
TLDR
Preliminary findings in a small group of patients with Graves’ disease are consistent with earlier findings that thyroid replacement with T4-T3 combination improves mental functioning. Expand
Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials.
TLDR
T(4) monotherapy should remain the treatment of choice for clinical hypothyroidism, and no difference was found in the effectiveness of combination vs. monotherapy in the following symptoms. Expand
Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial.
TLDR
Treatment of primary hypothyroidism with combination levothyroxine plus liothyronine combined therapy demonstrated no beneficial changes in body weight, serum lipid levels, Hypothyroid symptoms as measured by a HRQL questionnaire, and standard measures of cognitive performance. Expand
Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial.
TLDR
The current data do not support the routine use of combined T(3) and T(4) therapy in hypothyroid patients with depressive symptoms and no improvement in self-rated mood and well-being scores is reported. Expand
Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism.
TLDR
It is concluded that in the doses used in this study, combined T(4)/T(3) treatment does not improve well-being, cognitive function, or quality of life compared with T( 4) alone. Expand
REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine.
TLDR
Until clear advantages of levothyroxine plus liothyronine are demonstrated, the administration of lev Timothyroxine alone should remain the treatment of choice for replacement therapy of hypothyroidism. Expand
Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine.
TLDR
The substitution of L-T(3) for L-t(4) at equivalent doses reduced body weight and resulted in greater thyroid hormone action on the lipid metabolism, without detected differences in cardiovascular function or insulin sensitivity. Expand
Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial.
TLDR
These results may be consistent with a subgroup of patients showing transient improvement after partial substitution with T(3) but do not provide conclusive evidence of specific benefit from partial substitution of T(4) by T( 3) in patients on T( 4) replacement. Expand
Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
TLDR
In patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function; this finding suggests a specific effect of the triiod Timothyronine normally secreted by the thyroid gland. Expand
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