Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.

  title={Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.},
  author={Todd Engerson and T G McKelvey and D B Rhyne and E B Boggio and Stephen Ansolabehere Jonathan Rodden James M. Snyder and Harold P. Jones},
  journal={The Journal of clinical investigation},
  volume={79 6},
In response to global ischemia, tissue xanthine dehydrogenase was converted to xanthine oxidase in all tissues with half-times of conversion at 37 degrees C of approximately 3.6, 6, 7, and 14 h for the liver, kidney, heart, and lung, respectively. The time course of enzyme conversion at 4 degrees C was greatly extended with half-conversion times of 6, 5, 5, and 6 d for the respective tissues. Increases in xanthine oxidase activity were accompanied by the appearance of a distinct new protein… CONTINUE READING
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