Conversion of trichloroacetic acid to dichloroacetic acid in biological samples.

  title={Conversion of trichloroacetic acid to dichloroacetic acid in biological samples.},
  author={M M Ketcha and David K. Stevens and D A Warren and C T Bishop and W T Brashear},
  journal={Journal of analytical toxicology},
  volume={20 4},
Trichloroethylene (TCE) has been identified as an environmental contaminant in groundwater. Trichloroacetic acid (TCA), dichloroacetic acid (DCA), chloral hydrate (CH), trichloroethanol (TCOH), and trichloroethanol glucuronide (TCOG) have been identified as metabolites of TCE. Studies have shown that TCA and DCA are toxicologically significant metabolites that can induce liver tumors in B6C3F1 mice. Methods for the analysis of these metabolites are important for conducting pharmacokinetic… CONTINUE READING

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