Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects.

  title={Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects.},
  author={Lewis E. Braverman and Sidney H Ingbar and Kenneth Sterling},
  journal={The Journal of clinical investigation},
  volume={49 5},
Studies of the possibility that thyroxine (T4) is converted to 3.5,3'-triiodo-L-thyronine (T3) in the extrathyroidal tissues in man have been conducted in 13 patients, all but two of whom were athyreotic or hypothyroid, and all of whom were receiving at least physiological replacement doses of synthetic sodium-L-thyroxine.T3 was found in the sera of all patients, in concentrations ranging between 243 and 680 ng/100 ml (normal range 170-270 ng/100 ml). These concentrations were far in excess of… CONTINUE READING
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