Conversion of the high-yield salinomycin producer Streptomyces albus BK3-25 into a surrogate host for polyketide production

@article{Zhang2017ConversionOT,
  title={Conversion of the high-yield salinomycin producer Streptomyces albus BK3-25 into a surrogate host for polyketide production},
  author={Xiaojie Zhang and Chenyang Lu and Lin-quan Bai},
  journal={Science China Life Sciences},
  year={2017},
  volume={60},
  pages={1000-1009}
}
An ideal surrogate host for heterologous production of various natural products is expected to have efficient nutrient utilization, fast growth, abundant precursors and energy supply, and a pronounced gene expression. Streptomyces albus BK3-25 is a high-yield industrial strain producing type-I polyketide salinomycin, with a unique ability of bean oil utilization. Its potential of being a surrogate host for heterologous production of PKS was engineered and evaluated herein. Firstly, introduction… CONTINUE READING
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