Conversion of some 2(3H)-furanones bearing a pyrazolyl group into other heterocyclic systems with a study of their antiviral activity.

@article{Hashem2007ConversionOS,
  title={Conversion of some 2(3H)-furanones bearing a pyrazolyl group into other heterocyclic systems with a study of their antiviral activity.},
  author={Ahmed I. Hashem and Ahmed Sayed Youssef and Kamal A. Kandeel and Wael S. I. Abou-Elmagd},
  journal={European journal of medicinal chemistry},
  year={2007},
  volume={42 7},
  pages={934-9}
}
3-(1,3-diphenylpyrazol-4-yl-methylene)-5-aryl-2(3H)-furanones 2 were prepared and converted into a variety of heterocyclic systems of synthetic and biological importance. Benzylamine reacted with the furanones 2; the product was found to depend on the reaction conditions. Thus, at room temperature the open-chain N-benzylamides 3 were obtained, whereas under refluxing conditions the 2(3H)-pyrrolones were obtained. Hydrazine hydrate affected ring opening of the furanones to give the corresponding… CONTINUE READING
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