Conversion of normal rats into SCID-like animals by means of bone marrow transplantation from SCID donors allows engraftment of human peripheral blood mononuclear cells.

@article{Lubin1995ConversionON,
  title={Conversion of normal rats into SCID-like animals by means of bone marrow transplantation from SCID donors allows engraftment of human peripheral blood mononuclear cells.},
  author={Ido Lubin and Harry Segall and Porat Erlich and Muriel {\'A}lvaro David and Hadar Marcus and Gil Fire and Tatyana Burakova and Lydia Kulova and Yair Reisner},
  journal={Transplantation},
  year={1995},
  volume={60 7},
  pages={
          740-7
        }
}
We have recently shown that lethally irradiated normal strains of mice, radioprotected with SCID bone marrow, can be engrafted with human peripheral blood mononuclear cells (PBMC). We now demonstrate that lethally irradiated Lewis rats can also be radioprotected with a transplant of SCID bone marrow cells, administered 1 day after total body irradiation. Split chimerism was found in PBMC, 30 days after transplantation, with predominance of SCID donor-type cells. The average percentages of CD4… CONTINUE READING
BETA