Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

@article{Cobaleda2007ConversionOM,
  title={Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors},
  author={C{\'e}sar Cobaleda and Wolfram Jochum and Meinrad Busslinger},
  journal={Nature},
  year={2007},
  volume={449},
  pages={473-477}
}
Lineage commitment and differentiation to a mature cell type are considered to be unidirectional and irreversible processes under physiological conditions. The commitment of haematopoietic progenitors to the B-cell lineage and their development to mature B lymphocytes critically depend on the transcription factor encoded by the paired box gene 5 (Pax5). Here we show that conditional Pax5 deletion in mice allowed mature B cells from peripheral lymphoid organs to dedifferentiate in vivo back to… CONTINUE READING
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