Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models.

@article{Islam2014ConversionOM,
  title={Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models.},
  author={Mohammed A. Islam and Ans Punt and Bert Spenkelink and Albertinka Jacoba Murk and F X Rolaf van Leeuwen and Ivonne Mcm Rietjens},
  journal={Molecular nutrition & food research},
  year={2014},
  volume={58 3},
  pages={
          503-15
        }
}
SCOPE This study compares conversion of three major soy isoflavone glucosides and their aglycones in a series of in vitro intestinal models. METHODS AND RESULTS In an in vitro human digestion model isoflavone glucosides were not deconjugated, whereas studies in a Caco-2 transwell model confirmed that deconjugation is essential to facilitate transport across the intestinal barrier. Deconjugation was shown upon incubation of the isoflavone glucosides with rat as well as human intestinal S9. In… CONTINUE READING
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