Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

@article{Levine1993ConversionOL,
  title={Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene},
  author={Beth Levine and Qi F. Huang and John T Isaacs and John C. Reed and Diane E Griffin and Jonathan Hardwick},
  journal={Nature},
  year={1993},
  volume={361},
  pages={739-742}
}
LITTLE is known about virus–host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a single-stranded positive-sense RNA virus in the alphavirus genus (family Togaviridae), results in lytic infection in most vertebrate cell lines, but persistent productive infection in post-mitotic neurons1. The cellular oncogene bcl-2, which encodes an inner mitochondrial membrane protein of Mr 26,000 (ref. 2), blocks programmed cell death… CONTINUE READING

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