Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes.

@article{Isseroff1987ConversionOL,
  title={Conversion of linoleic acid into arachidonic acid by cultured murine and human keratinocytes.},
  author={Roslyn Rivkah Isseroff and Vincent A. Ziboh and Robert S. Chapkin and Dan Martinez},
  journal={Journal of lipid research},
  year={1987},
  volume={28 11},
  pages={1342-9}
}
The origin of arachidonic acid (AA) found in the epidermis is not known. Two possibilities exist: either de novo synthesis within the epidermal keratinocyte, or transport of AA formed at distant tissue sites. The current study examined the ability of cultured murine and human keratinocytes to metabolize exogenously added linoleic acid (LA). Conversion of radiolabeled substrate (14C-LA) into 18:3(n-6), 20:2(n-6), 20:3(n-6), and 20:4(n-6) (AA) was noted. The conversion of non-radiolabeled 18:3(n… CONTINUE READING
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