Conversion of dorsal from an activator to a repressor by the global corepressor Groucho.

@article{Dubnicoff1997ConversionOD,
  title={Conversion of dorsal from an activator to a repressor by the global corepressor Groucho.},
  author={T. Dubnicoff and S. A. Valentine and G. Chen and T. Shi and J. Lengyel and Z. Paroush and A. Courey},
  journal={Genes \& development},
  year={1997},
  volume={11 22},
  pages={
          2952-7
        }
}
The Dorsal morphogen acts as both an activator and a repressor of transcription in the Drosophila embryo to regulate the expression of dorsal/ventral patterning genes. Circumstantial evidence has suggested that Dorsal is an intrinsic activator and that additional factors (corepressors) convert it into a repressor. These corepressors, however, have previously eluded definitive identification. We show here, via the analysis of embryos lacking the maternally encoded Groucho corepressor and via… Expand
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Uncoupling Dorsal-mediated activation from Dorsal-mediated repression in the Drosophila embryo
Groucho: a corepressor with instructive roles in development.
Activation and repression by the C-terminal domain of Dorsal.
Regulation of dorso/ventral patterning in the drosophila embryo by multiple dorsal-interacting proteins
The Dorsal Rel Homology Domain Plays an Active Role in Transcriptional Regulation
Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal
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